Abstract
Intraperitoneal administration of magnolol (25-100 mg/kg) produced a dose-related fall in rats' colonic temperature. The magnolol-induced hypothermia was attenuated by pretreatment with intracerebroventricular 6-hydroxydopamine (200 microg/rat). The L-DOPA (200 mg/kg, i.p.) plus benserazide (50 mg/kg, i.p.)-induced hyperthermia was attenuated by magnolol. On the other hand, the alpha-methyltyrosine (100 mg/kg, i.p.)-induced hypothermia was potentiated by magnolol. Furthermore, magnolol (50 mg/kg, i.p.) decreased the dopamine and norepinephrine release in the hypothalamus, but did not change the concentrations for their metabolites (3,4-dihydroxyphenylacetic acid and homovanillic acid). The data suggest that magnolol decreases colonic temperature by reducing catecholaminergic activity in rat hypothalamus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3,4-Dihydroxyphenylacetic Acid / metabolism
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Adrenergic Agents / pharmacology
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Animals
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Anti-Anxiety Agents / pharmacology*
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Biphenyl Compounds / pharmacology*
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Body Temperature / drug effects
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Catecholamines / physiology*
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Colon / drug effects
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Colon / physiology
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Dopamine / metabolism
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Dopamine Agents / pharmacology
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / pharmacology
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Epinephrine / metabolism
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Homovanillic Acid / metabolism
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Hypothalamus / drug effects
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Hypothalamus / metabolism
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Hypothermia, Induced*
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Injections, Intraperitoneal
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Injections, Intraventricular
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Levodopa / pharmacology
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Lignans*
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Male
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Norepinephrine / metabolism
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Oxidopamine / pharmacology
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Rats
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Rats, Sprague-Dawley
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alpha-Methyltyrosine / pharmacology
Substances
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Adrenergic Agents
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Anti-Anxiety Agents
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Biphenyl Compounds
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Catecholamines
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Dopamine Agents
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Enzyme Inhibitors
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Lignans
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magnolol
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3,4-Dihydroxyphenylacetic Acid
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Levodopa
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alpha-Methyltyrosine
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Oxidopamine
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Dopamine
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Norepinephrine
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Homovanillic Acid
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Epinephrine