Abstract
Pseudomonas aeruginosa has two complete quorum-sensing systems. Both of these systems have been shown to be important for Pseudomonas virulence in multiple models of infection. Thus, these systems provide unique targets for novel antimicrobial drugs.
MeSH terms
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Anti-Infective Agents / pharmacology*
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Anti-Infective Agents / therapeutic use*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Cell Communication / physiology
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Gene Expression Regulation, Bacterial
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Humans
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Pseudomonas Infections / drug therapy*
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / genetics
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Pseudomonas aeruginosa / pathogenicity*
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Pseudomonas aeruginosa / physiology
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Virulence Factors / genetics
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Virulence Factors / metabolism
Substances
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Anti-Infective Agents
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Bacterial Proteins
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DNA-Binding Proteins
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LasI protein, Pseudomonas aeruginosa
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LasR protein, Pseudomonas aeruginosa
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Trans-Activators
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Virulence Factors