Characteristics of study population
| Clinical data | PCD | Sinusitis | Controls | Tukey’s test | ||
| P PCD /sinusitis | P PCD /controls | P sinusitis/ controls | ||||
| Subjects, n | 62* | 25 | 43 | – | – | – |
| Men n (%)† | 31 (50) | 14 (56) | 19 (44) | – | – | – |
| Children n (%) | 23 (37) | 10 (40) | 16 (37) | – | – | – |
| Age, years, median (L-UQ) | 21.4 (15.9 to 36.1) | 21.5 (14.9 to 40.2) | 26.3 (11.9 to 28.6) | 0.879 | 0.359 | 0.276 |
| Nasal nitric oxide, nL/min median (L-UQ) | 31.8 (16.3 to 49.8) | 77.6 (72.0 to 82.2) | 200.7 (197.9 to 201.7) | <0.0001 | <0.0001 | <0.0001 |
| Olfactory assessment (mean) | ||||||
| Threshold (95% CI) | 3.6 (3.0 to 4.2) | 4.6 (4.2 to 4.9) | 6.2 (5.9 to 6.5) | 0.040 | <0.0001 | <0.001 |
| Discrimination (95% CI) | 8.4 (7.2 to 9.4) | 11.5 (10.8 to 11.9) | 12.3 (11.8 to 12.8) | 0.001 | <0.0001 | 0.479 |
| Blue identification (95% CI) | 9.3 (8.2 to 10.2) | 11.6 (11.1 to 12.2) | 12.5 (11.7 to 13.2) | 0.007 | <0.0001 | 0.513 |
| Purple identification (95% CI) | 8.6 (7.6 to 9.6) | 11.7 (11.1 to 12.1) | 12.6 (12.0 to 13.2) | 0.0002 | <0.0001 | 0.447 |
| TDI score (95% CI) | 21.2 (18.7 to 23.6) | 27.6 (26.6 to 28.6) | 31.1 (29.9 to 32.2) | 0.001 | <0.0001 | 0.142 |
| TDI extended score (95% CI) | 29.8 (26.4 to 33.2) | 39.3 (37.9 to 40.6) | 43.7 (42.1 to 45.3) | 0.0003 | <0.0001 | 0.187 |
| CT scanning of paranasal sinuses | ||||||
| Modified Lund-Mackay score, median (L-UQ) | 12.0 (9.8 to 17.7) | 11.0 (9.0 to 14.0) | NA | 0.100 | – | – |
| Sinus aplasia or hypoplasia score, median (L-UQ) | 3.0 (0.0 to 4.0) | 3.0 (1.25 to 4.0) | NA | 0.920 | – | – |
*CT scanning of paranasal sinuses in 57 patients with PCD.
†Men vs women: P=0.634 (χ2 test).
L-UQ, lower–upper quartile; NA, not applicable; PCD, primary ciliary dyskinesia; TDI,Threshold Discrimination Identification.