Physical activity, cardiovascular markers and ventilatory function
| Bi-level PAP | CPAP | ||||
|---|---|---|---|---|---|
| Baseline | 3 months | Baseline | 3 months | p Value | |
| Cardiovascular markers | |||||
| Haemoglobin | 145 (3.6) | 148 (3.6) | 145 (3.4) | 140 (3.5) | Group 0.99, time <0.41 Interaction 0.09 |
| Haemoglobin A1C | 6.79 (0.22) | 6.45 (0.22) | 6.62 (0.21) | 6.50 (0.21) | Group 0.58, time 0.03 Interaction 0.28 |
| CRP | 10.4 (2.1) | 8.1 (2.1) | 17.3 (2.0) | 11.7 (2.0) | Group 0.02, time <0.25 Interaction 0.23 |
| Total cholesterol | 4.31 (0.20) | 4.96 (0.20) | 4.33 (0.19) | 4.89 (0.19) | Group 0.96, time <0.01 Interaction 0.78 |
| HDL | 1.04 (0.058) | 1.15 (0.058) | 1.11 (0.055) | 1.12 (0.055) | Group 0.39, time 0.01 Interaction 0.09 |
| LDL | 2.58 (0.18) | 2.95 (0.18) | 2.55 (0.17) | 2.91 (0.17) | Group 0.90, time 0.06 Interaction 0.97 |
| TSH | 3.06 (0.44) | 2.43 (0.45) | 2.07 (0.43) | 2.09 (0.43) | Group 0.11, time <0.13 Interaction 0.26 |
| Blood pressure—systolic | 135 (3.7) | 137 (4.1) | 134 (3.8) | 137 (3.8) | Group 0.80, time 0.63 Interaction 0.90 |
| Blood pressure—diastolic | 77 (2.4) | 78 (2.6) | 76 (2.4) | 80 (2.4) | Group 0.58, time 0.93 Interaction 0.23 |
| Respiratory muscle pressures | |||||
| MIP % predicted | 56.2 (4.7) | 66.5 (4.8) | 46.6 (4.6) | 54.6 (4.6) | Group 0.14, time 0.01 Interaction 0.66 |
| MEP % predicted | 91.3 (5.4) | 85.6 (5.6) | 85.3 (5.2) | 90.9 (5.3) | Group 0.42, time 0.19 Interaction 0.006 |
| SNIP % predicted | 71.7 (5.2) | 81.7 (5.2) | 63.0 (4.4) | 73.6 (4.4) | Group 0.20, time 0.03 Interaction 0.91 |
| Physical activity | |||||
| Sedentary time awake min/day | 937 (35.6) | 902 (38.2) | 914 (33.0) | 872 (32.1) | Group 0.63, time 0.28 Interaction 0.88 |
| MVPA min/day * | 14.5 (4.1–33.4) | 19.7 (2.3–34.5) | 9.0 (2.1–29.2) | 18.5 (7.2–42.7) | Group 0.63 Time 0.27 |
| Steps/day | 4135 (689) | 4332 (730) | 3847 (635) | 5059 (621) | Group 0.76, time p=0.73 Interaction 0.18 |
Values represent estimated marginal means (SE) from mixed model analysis for cardiovascular risk markers, pulmonary function and physical activity, except for * represents median (IQR). Significance results are for the effects of group (Bi-level PAP vs CPAP), time (baseline vs 3 months) and their interaction.
CRP, C reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MEP, maximal expiratory pressure; MIP, maximal inspiratory pressure; MVPA, moderate-to-vigorous physical activity; PAP, positive airways pressure; SNIP, sniff inspiratory pressure; TSH, thyroid-stimulating hormone.