Table 2

Cost of screening and treatment per patient (2009 US$)

	Provider cost	Patient cost	Total cost
Component costs
Clinic visit	12.8	10.9	23.7
Hospital outpatient visit	51.8	10.9	62.7
Hospital inpatient stay (per day)	155.3	0	155.3
TST (disposables, nurse administration and reading)	17.4	21.8	39.2
Chest radiography (includes reading and reporting)	30.6	10.9	41.5
TB culture and drug sensitivity testing	50.7	0	50.7
CT scan (includes reading and reporting)	211.4	0	211.4
Cerebral spinal fluid analysis	25.7	0	25.7
Liver function tests	36.1	0	36.1
HIV testing	4·3	0	4.3
Unit costs
Screening with TST^*	77.9	21.8	99.7
Screening with T-SPOT.TB^*	194.2	32.6	226.8
Screening with QuantiFERON^*	172.9	32.6	205.5
Screening with TST + T-SPOT.TB^*	211.5	32.6	244.1
Screening with TST + QuantiFERON^*	190.2	32.6	222.8
Isoniazid preventive therapy course^†	64.9	54.3	119.2
Pulmonary TB treatment^‡
Age 0–2	802.7	86.9	907.6
Age 3–5	1272.1	86.9	1359.0
Miliary TB treatment (excluding TB meningitis)^§ ^**
Age 0–2	2233.9	108.6	3342.5
Age 3–5	3911.0	108.6	4019.6
TB meningitis treatment^¶ ^**
Age 0–2	28798.5	108.6	28907.1
Age 3–5	29249.9	108.6	29358.5
Disseminated TB treatment^**
Age 0–2	16016.2	108.6	16124.8
Age 3–5	16580.4	108.6	16689.0

↵* The costs for all screening strategies include the costs of the tests (disposables, administration, reading, laboratory technicians), two clinic visits and one chest radiograph. Screening strategies that include an IGRA also include the cost of one outpatient laboratory visit.
↵† Assumes that children receive five doses of INH per week for 6 months and complete five outpatient clinic visits.
↵‡ Assumes that all children receive five doses of combination therapy per week for 6 months, are hospitalised for 1 day and complete seven outpatient clinic visits, one TST, two chest radiographs and two TB cultures; it is assumed that 30% of children will complete drug sensitivity testing.
↵§ Assumes that all children receive five doses of combination therapy per week for 9 months, are hospitalised for 15 days, and complete eight outpatient clinic visits, one TST, two chest radiographs and two TB cultures; it is assumed that 30% of children will complete drug sensitivity testing.
↵¶ Assumes that all children receive five doses of combination therapy per week for 6 months, are hospitalised for 6 months, and complete two outpatient clinic visits, one TST, two chest radiographs, two TB cultures, one CT scan, and one evaluation of cerebrospinal fluid; it is assumed that 30% of children will complete drug sensitivity testing.
↵** Assumes that the cost of disseminated TB is 50% of the cost of miliary TB and 50% of the cost of TB meningitis.
TB, tuberculosis; TST, tuberculin skin test.