Table 4 Bioinformatic indications of transcription factor activity
TFBMRatio*p Value
Univariate†Random‡Sensitivity§
V$CP2_012.330.01560.01140.0943
V$TAL1BETAITF2_017.620.01660.00840.0922
V$NFY_C0.280.02230.02120.0485
V$CREB_Q40.450.03060.03340.0056
V$NFKB_Q62.540.03160.02320.0200
V$SREBP1_014.500.03910.03160.0759
V$COUP_014.850.04340.03600.0926
V$HSF2_010.710.04350.04600.0513
V$AP1FJ_Q20.650.04640.04840.0005
V$VJUN_010.200.04770.05120.0342
  • *TFBM prevalence in promoters of genes overexpressed in T lymphocytes from the low versus the high SES groups.

  • †p Value from unequal variance Welch t test of TFBM prevalence.

  • ‡p Value based on 10 000 random samples of 60 human genes.

  • §p Value for average over nine combinations of three promoter lengths (−300 bp, −600 bp, −1000 to +200 bp) and 3 TFBM detection stringencies (MatSim 0.80, 0.90, and 0.95)

  • SES, socioeconomic status; TFBM, transcription factor binding motif.