Contribution of D genotype to LAA score, Kco, and FEV1.0 independent of age and cigarette consumption in logistic regression analysis
| Definition | Independent factor | χ2 | p value | Odds ratio | 95% CI |
|---|---|---|---|---|---|
| CI= confidence interval; LAA=low attenuation area score; CC=lifelong cigarette consumption; Kco=carbon monoxide transfer coefficient; FEV1.0=forced expiratory volume in 1 second. | |||||
| *p<0.05, **p<0.01. | |||||
| Odds ratio and 95% CI correspond to having genotype D, aging every 10 years, or 10 pack years increase in CC. | |||||
| LAA ≥8 (76/203, 37%) | Genotype D | 6.41 | 0.01* | 0.40 | 0.20 to 0.81 |
| Age (10 years) | 7.48 | 0.01* | 1.58 | 1.14 to 2.18 | |
| CC (10 pack years) | 0.29 | 0.59 | 1.03 | 0.94 to 1.12 | |
| %Kco <65 (55/170, 32%) | Genotype D | 4.57 | 0.03* | 0.40 | 0.17 to 0.93 |
| Age (10 years) | 14.46 | <0.01** | 2.19 | 1.46 to 3.29 | |
| CC (10 pack years) | 0.85 | 0.36 | 1.05 | 0.95 to 1.17 | |
| %FEV1.0 <50 (57/203, 28%) | Genotype D | 0.43 | 0.51 | 0.78 | 0.37 to 1.64 |
| Age (10 years) | 14.34 | <0.01** | 2.04 | 1.41 to 2.95 | |
| CC (10 pack years) | 1.78 | 0.18 | 1.07 | 0.97 to 1.17 | |