Prognostic markers significantly associated with mortality in ICU admissions of HIV positive patients with Pneumocystis carinii pneumonia (PCP) requiring mechanical ventilation
| HIV related PCP episodes studied (n) | Period of study | Prognostic markers associated with ICU mortality* | Reference |
|---|---|---|---|
| *Rows cannot be directly compared since studies considered different sets of variables. In most of the studies shown here a low CD4 cell count is taken to mean <200 cells/mm3. | |||
| **This study was limited to patients with CD4 count <200 cells/mm3 and on ICU with mechanical ventilation. Mortality varied significantly depending on CD4 counts: >100 cells/mm3, 25%; 51–100 cells/mm3, 50%; 11–50 cells/mm3, 88%; 0–10 cells/mm3, 100%. | |||
| 110 | 1989–94 | Respiratory status deterioration requiring delayed mechanical ventilation; mechanical ventilation for 5 days or more; nosocomial infection, pneumothorax | 33 |
| 48* | 1993–96 | Low CD4 cell count within 2 weeks of admission** | 40 |
| 176 | 1990–99 | Low CD4 cell count; prior PCP prophylaxis, CMV in BAL fluid, age, initial anti-PCP therapy | 9 |
| 155 | 1995–97 | Prior PCP prophylaxis | 34 |
| 21 | 1993–98 | High APACHE II score >17, low serum albumin <25 g/l, ARDS, low CD4 cell count <150 cells/mm3, arterial pH <7.35 | 42 |