Mean (SD) lung function and haemodynamic indices in 171 patients with PPH subdivided into groups according to median mean pulmonary artery pressure (PAPmean)
| PAPmean ≤56 mm Hg | PAPmean >56 mm Hg | Mean difference | ||
|---|---|---|---|---|
| (n=86) | (n=85) | (95% CI) | p value* | |
| CI = confidence interval; PAPmean = mean pulmonary artery pressure; CVP = central venous pressure; PCWP = postcapillary wedge pressure; PVR = pulmonary vascular resistance; TLC = total lung capacity; RV = residual volume; Rtot = airway resistance; VC = vital capacity; FEV1 = forced expiratory volume in 1 second; PEF = peak expiratory flow; MEF75, 50, 25 = maximal expiratory flow at 25%, 50%, and 75% of exhaled VC, respectively. 7.5 mm Hg = 1 kPa. *Student's t test. | ||||
| PAPmean (mm Hg) | 47 (7) | 68 (12) | −21 (−23.9 to −18.1) | <0.001 |
| CVP (mm Hg) | 6 (4) | 10 (5) | −4 (−5.4 to −2.6) | <0.001 |
| PCWP (mm Hg) | 7 (3) | 8 (3) | −1 (−1.9 to −0.1) | 0.048 |
| PVR (dyne.s/cm5) | 1029 (431) | 1784 (667) | −755 (−923.1 to −586.9) | <0.001 |
| Cardiac output (l/min) | 3.6 (1.1) | 3.1 (1.2) | −0.5 (0.2 to 0.9) | 0.026 |
| TLC (% predicted) | 99 (18) | 96 (13) | 3 (−1.7 to 7.7) | 0.2 |
| RV (% predicted) | 113 (33) | 122 (32) | −9 (−18.8 to 0.8) | 0.07 |
| RV/TLC (% predicted) | 111 (22) | 125 (32) | −14 (−22.2 to −5.8) | 0.006 |
| Rtot (% of upper limit) | 95 (46) | 101 (39) | −6 (−18.8 to 6.8) | 0.26 |
| VC (% predicted) | 94 (15) | 87 (15) | 7 (2.5 to 11.5) | <0.001 |
| FEV1 (% predicted) | 87 (15) | 80 (16) | 7 (2.4 to 11.7) | 0.006 |
| FEV1/VC (%) | 75 (8) | 77 (10) | −2 (−4.7 to 0.7) | 0.2 |
| PEF (% predicted) | 88 (21) | 81 (21) | 7 (0.7 to 13.3) | 0.045 |
| MEF75 (% predicted) | 84 (23) | 80 (24) | 4 (−3.1 to 11.1) | 0.37 |
| MEF50 (% predicted) | 66 (23) | 66 (26) | 0 (7.4 to 7.4) | 0.96 |
| MEF25 (% predicted) | 46 (24) | 46 (26) | 0 (7.5 to 7.5) | 0.98 |