Table 6

Table 6

Anxiety and COPD-related health outcomes: potential mediation by disease severity

Outcome measure	Change in each outcome for anxious vs non-anxious*
Outcome measure	Multivariable adjusted*	Multivariable adjusted + COPD severity†
Physical health status (points)	−4.66 (−6.44 to −2.89)	−2.61 (−4.12 to −1.10)
Physical health status (points)	p<0.0001	p=0.0007
Disease-specific HRQL (points)	3.31 (2.62 to 4.00)	2.39 (1.83 to 2.94)
Disease-specific HRQL (points)	p<0.0001	p<0.00001
Distance walked in 6 min (feet)	−66.3 (−127.3 to −5.36)	8.1 (−38.4 to 54.6)
Distance walked in 6 min (feet)	p=0.033	p=0.73
Risk of self-reported physical functional limitations	OR 2.41 (1.71 to 3.41)	OR 1.99 (1.34 to 2.95)
Risk of self-reported physical functional limitations	p<0.0001	p=0.0007
Longitudinal risk of COPD exacerbation	HR 1.39 (1.007 to 1.90)	HR 1.052 (0.76 to 1.45)
Longitudinal risk of COPD exacerbation	p=0.045	p=0.76

Multivariable analysis adjusted for age, sex, race, educational attainment, household income and smoking history.
↵* This column summarises multivariable results from tables 4 and 5 for comparison with severity-adjusted results.
↵† Models also include both COPD severity score and BODE index as measures of COPD severity.
COPD, chronic obstructive pulmonary disease; HRQL, health-related quality of life.