HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Egan, J J Articles by Williams, T Search for Related Content PubMed PubMed Citation Articles by Egan, J J Articles by Williams, T

Lung function estimates in idiopathic pulmonary fibrosis: the potential for a simple classification

¹ The Mater Misericordiae Hospital and St Vincent’s University Hospital, The Conway Institute, Dublin Molecular Medicine Center, University College Dublin, Ireland
² Taubman Center 3916, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0360, USA
³ Interstitial Lung Disease Unit, Emmanuel Kaye Building, Manresa Road, London SW6 LR6, UK
⁴ Alfred Hospital, Monash University, Melbourne, Australia

Correspondence to:
Correspondence to:
Dr J Egan
Advanced Lung Disease and Irish National Lung Transplant Program, The Mater Misericordiae Hospital and St Vincent’s University Hospital, The Conway Institute, Dublin Molecular Medicine Center, University College Dublin, Ireland; jegan@mater.ie

Abbreviations: BOS, bronchiolitis obliterans syndrome; COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; IIP, idiopathic interstitial pneumonia; IPF, idiopathic pulmonary fibrosis; NSIP, ; non-specific interstitial pneumonia, ; TLC, total lung capacity; TLCO, carbon monoxide lung transfer factor; UIP, usual interstitial pneumonia

Keywords: idiopathic pulmonary fibrosis; lung function; classification

The first 150 words of the full text of this article appear below.

For many years the idiopathic pulmonary fibrosis (IPF) community has debated the merits of the histopathological classification of idiopathic interstitial pneumonia (IIP).¹ The ATS/ERS consensus statement identifies the importance of histological categories of usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP). Furthermore, it emphasises that IPF is the clinical correlate of UIP. Despite the recognition of the importance of histological characterisation, surgical biopsy rates vary considerably.² Most clinicians do not subject their patients to surgical biopsy, despite the potential prognostic benefit of detailed histological evaluation, because many patients are elderly and have significantly impaired lung function and other medical co-morbidities resulting in a potentially high mortality rate.³ In addition, HRCT scanning provides diagnostic data of high sensitivity and specificity for the diagnosis of IPF with acceptable interobserver variability.^4,5

Meanwhile, the chronic obstructive pulmonary disease (COPD) and lung transplantation communities have applied simple but pragmatically . . . [Full text of this article]

This article has been cited by other articles:

				A U Wells, N Hirani, and on behalf of the BTS Interstitial Lung Disease Gui Interstitial lung disease guideline Thorax, September 1, 2008; 63(Suppl_5): v1 - v58. [Full Text] [PDF]

				I. Noth and F. J. Martinez Recent Advances in Idiopathic Pulmonary Fibrosis Chest, August 1, 2007; 132(2): 637 - 650. [Abstract] [Full Text] [PDF]

				M. Alakhras, P. A. Decker, H. F. Nadrous, M. Collazo-Clavell, and J. H. Ryu Body Mass Index and Mortality in Patients With Idiopathic Pulmonary Fibrosis Chest, May 1, 2007; 131(5): 1448 - 1453. [Abstract] [Full Text] [PDF]

				O.J. Dempsey, K.M. Kerr, L. Gomersall, H. Remmen, and G.P. Currie Idiopathic pulmonary fibrosis: an update QJM, October 1, 2006; 99(10): 643 - 654. [Abstract] [Full Text] [PDF]

				K. R. Flaherty, A.-C. Andrei, S. Murray, C. Fraley, T. V. Colby, W. D. Travis, V. Lama, E. A. Kazerooni, B. H. Gross, G. B. Toews, et al. Idiopathic Pulmonary Fibrosis: Prognostic Value of Changes in Physiology and Six-Minute-Walk Test Am. J. Respir. Crit. Care Med., October 1, 2006; 174(7): 803 - 809. [Abstract] [Full Text] [PDF]

				F. J. Martinez and M. P. Keane Update in diffuse parenchymal lung diseases 2005. Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1066 - 1071. [Full Text] [PDF]

				S. P. Crowley, P. Kelly, and J. J. Egan Acute Exacerbations in Idiopathic Pulmonary Fibrosis Ann Intern Med, February 7, 2006; 144(3): 218 - 218. [Full Text] [PDF]

				P. Pignatti, G. Brunetti, D. Moretto, M.-R. Yacoub, M. Fiori, B. Balbi, A. Balestrino, G. Cervio, S. Nava, and G. Moscato Role of the Chemokine Receptors CXCR3 and CCR4 in Human Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., February 1, 2006; 173(3): 310 - 317. [Abstract] [Full Text] [PDF]

				F. J. Martinez Idiopathic Interstitial Pneumonias: Usual Interstitial Pneumonia versus Nonspecific Interstitial Pneumonia. Proceedings of the ATS, January 1, 2006; 3(1): 81 - 95. [Abstract] [Full Text] [PDF]

				F. J. Martinez and K. Flaherty Pulmonary function testing in idiopathic interstitial pneumonias. Proceedings of the ATS, January 1, 2006; 3(4): 315 - 321. [Abstract] [Full Text] [PDF]