| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ASTHMA |
-308 gene promoter and asthma: a meta-analysis
1 Department of Respiratory Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China
2 Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100005, China
3 Hypertension and Atherosclerosis Section, Boston University School of Medicine, Boston, MA 02118, USA
4 Asthma and Allergy Research Institute and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, WA 6009, Australia
5 Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Correspondence to:
Correspondence to:
Dr J Gao
Department of Respiratory Diseases, Peking Union Medical College Hospital, 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China; gaojm{at}pumch.ac.cn
Background: Asthma is a complex polygenic disease in which gene–environment interactions are important. The gene encoding tumour necrosis factor alpha (TNF
) is one of several candidate loci for asthma pathogenesis and is highly polymorphic. A number of studies have investigated the polymorphism of TNF-308 gene promoter (substitution G
A, designated as TNF1 and TNF2) in relation to asthma susceptibility in different populations. However, the results of individual studies have been inconsistent.
Methods: To address the inconsistent findings in studies of the association of the polymorphism of TNF-308 gene promoter with susceptibility to asthma, a systematic review was undertaken of the published data and a meta-analysis was performed. The MEDLINE database was searched for case-control studies published in English language journals from 1966 to October 2005. Data were extracted using standardised forms and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
Results: Fifteen eligible studies, comprising 2409 patients with asthma and 3266 controls, were included in the meta-analysis. Using the random effects model, the pooled result showed that the TNF2 allele is associated with overall susceptibility to asthma (OR 1.37, 95% CI 1.02 to 1.84, p = 0.04). The ORs for asthma susceptibility in TNF2 homozygote individuals were significantly increased at 2.01 (95% CI 1.26 to 3.20, p = 0.009) and 1.51 (95% CI 1.02 to 2.22, p = 0.041) compared with TNF1 homozygotes and TNF2/1 heterozygotes, respectively. In addition, the pooled OR for asthma risk in TNF2/1 heterozygotes was also significantly higher than that in TNF1/1 homozygotes (OR 1.47, 95% CI 1.01 to 2.13, p = 0.045).
Conclusions: The TNF2 allele confers a significant risk for developing asthma. A large scale case-control study is needed to clarify the functional effect of the polymorphism of the TNF gene in the pathogenesis of asthma.
Abbreviations: TNF, tumour necrosis factor alpha
Keywords: asthma; genetics; tumour necrosis factor; polymorphism; meta-analysis
This article has been cited by other articles:
|
|
 |
|
  J B Morjaria, A J Chauhan, K S Babu, R Polosa, D E Davies, and S T Holgate The role of a soluble TNF{alpha} receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial Thorax, July 1, 2008; 63(7): 584 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. DeMeo, E. J. Campbell, A. F. Barker, M. L. Brantly, E. Eden, N. G. McElvaney, S. I. Rennard, R. A. Sandhaus, J. M. Stocks, J. K. Stoller, et al. IL10 Polymorphisms Are Associated with Airflow Obstruction in Severe {alpha}1-Antitrypsin Deficiency Am. J. Respir. Cell Mol. Biol., January 1, 2008; 38(1): 114 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Beleza-Meireles, I. Kockum, F. Lundberg, C. Soderhall, and A. Nordenskjold Risk Factors for Hypospadias in the Estrogen Receptor 2 Gene J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3712 - 3718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-W. Park, E.-S. Shin, J.-E. Lee, H.-S. Kwon, E. Chun, S.-S. Kim, Y.-S. Chang, Y.-K. Kim, K.-U. Min, Y.-Y. Kim, et al. Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction Thorax, March 1, 2007; 62(3): 265 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sharma, A. Sharma, S. Kumar, S. K. Sharma, and B. Ghosh Association of TNF Haplotypes with Asthma, Serum IgE Levels, and Correlation with Serum TNF-{alpha} Levels Am. J. Respir. Cell Mol. Biol., October 1, 2006; 35(4): 488 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-A. Krayenbuehl, F. E. Maly, M. Hersberger, P. Wiesli, A. Himmelmann, K. Eid, P. Greminger, W. Vetter, and G. Schulthess Tumor Necrosis Factor-{alpha} -308G>A Allelic Variant Modulates Iron Accumulation in Patients with Hereditary Hemochromatosis Clin. Chem., August 1, 2006; 52(8): 1552 - 1558. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
