| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
REVIEW SERIES |
Academic Unit of Respiratory Medicine, University College London, London, UK
Correspondence to:
Correspondence to:
Professor J A Wedzicha
Royal Free & University College Medical School, Hampstead Campus, London NW3 2PF, UK;j.a.wedzicha{at}medsch.ucl.ac.uk
The epidemiology of exacerbations of chronic obstructive pulmonary disease (COPD) is reviewed with particular reference to the definition, frequency, time course, natural history and seasonality, and their relationship with decline in lung function, disease severity and mortality. The importance of distinguishing between recurrent and relapsed exacerbations is discussed.
Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; LRTI, lower respiratory tract infections; PEF, peak expiratory flow
Keywords: chronic obstructive pulmonary disease; exacerbations; epidemiology
This article has been cited by other articles:
|
|
 |
|
  W. Xu, J.-P. Collet, S. Shapiro, Y. Lin, T. Yang, R. W. Platt, C. Wang, and J. Bourbeau Independent Effect of Depression and Anxiety on Chronic Obstructive Pulmonary Disease Exacerbations and Hospitalizations Am. J. Respir. Crit. Care Med., November 1, 2008; 178(9): 913 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Suissa, P. Ernst, K. L. Vandemheen, and S. D. Aaron Methodological issues in therapeutic trials of COPD Eur. Respir. J., May 1, 2008; 31(5): 927 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Stolz, T. Breidthardt, M. Christ-Crain, R. Bingisser, D. Miedinger, J. Leuppi, B. Mueller, M. Tamm, and C. Mueller Use of B-Type Natriuretic Peptide in the Risk Stratification of Acute Exacerbations of COPD Chest, May 1, 2008; 133(5): 1088 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vestbo, W. Anderson, H. O. Coxson, C. Crim, F. Dawber, L. Edwards, G. Hagan, K. Knobil, D. A. Lomas, W. MacNee, et al. Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) Eur. Respir. J., April 1, 2008; 31(4): 869 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M T Dransfield, S M Rowe, J E Johnson, W C Bailey, and L B Gerald Use of {beta} blockers and the risk of death in hospitalised patients with acute exacerbations of COPD Thorax, April 1, 2008; 63(4): 301 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A B Chang and D Bilton Exacerbations in cystic fibrosis: 4 {middle dot} Non-cystic fibrosis bronchiectasis Thorax, March 1, 2008; 63(3): 269 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.C. Whiteman, Y. Yang, J.M. Jones, and M.A. Spiteri FTIR spectroscopic analysis of sputum: Preliminary findings on a potential novel diagnostic marker for COPD Therapeutic Advances in Respiratory Disease, February 1, 2008; 2(1): 23 - 31. [Abstract] [PDF]
|
|
|
|
 |
|
 E. K. Silverman Exacerbations in Chronic Obstructive Pulmonary Disease: Do They Contribute to Disease Progression? Proceedings of the ATS, December 1, 2007; 4(8): 586 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Foreman, D. L. DeMeo, C. P. Hersh, J. J. Reilly, and E. K. Silverman Clinical determinants of exacerbations in severe, early-onset COPD Eur. Respir. J., December 1, 2007; 30(6): 1124 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kobayashi, H. Kubo, and M. Yanai Impairment of the swallowing reflex in exacerbations of COPD Thorax, November 1, 2007; 62(11): 1017 - 1017. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Beaulieu-Genest, D. Chretien, F. Maltais, K. Pelletier, J.-G. Parent, and Y. Lacasse Self-administered prescriptions of oral steroids and antibiotics in chronic obstructive pulmonary disease: are we doing more harm than good? Chronic Respiratory Disease, August 1, 2007; 4(3): 143 - 147. [Abstract] [PDF]
|
|
|
|
|
|
K. F. Rabe, B. Beghe, F. Luppi, and L. M. Fabbri Update in Chronic Obstructive Pulmonary Disease 2006 Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1222 - 1232. [Full Text] [PDF]
|
|
|
|
|
|
D. Stolz, M. Christ-Crain, N. G. Morgenthaler, J. Leuppi, D. Miedinger, R. Bingisser, C. Muller, J. Struck, B. Muller, and M. Tamm Copeptin, C-Reactive Protein, and Procalcitonin as Prognostic Biomarkers in Acute Exacerbation of COPD Chest, April 1, 2007; 131(4): 1058 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Soriano, D. D. Sin, X. Zhang, P. G. Camp, J. A. Anderson, N. R. Anthonisen, A. S. Buist, P. S. Burge, P. M. Calverley, J. E. Connett, et al. A Pooled Analysis of FEV1 Decline in COPD Patients Randomized to Inhaled Corticosteroids or Placebo Chest, March 1, 2007; 131(3): 682 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J R Hurst and J A Wedzicha What is (and what is not) a COPD exacerbation: thoughts from the new GOLD guidelines Thorax, March 1, 2007; 62(3): 198 - 199. [Full Text] [PDF]
|
|
|
|
|
|
J A Wedzicha and J R Hurst Chronic obstructive pulmonary disease exacerbation and risk of pulmonary embolism Thorax, February 1, 2007; 62(2): 103 - 104. [Full Text] [PDF]
|
|
|
|
|
|
D. Stolz, M. Christ-Crain, R. Bingisser, J. Leuppi, D. Miedinger, C. Muller, P. Huber, B. Muller, and M. Tamm Antibiotic Treatment of Exacerbations of COPD: A Randomized, Controlled Trial Comparing Procalcitonin-Guidance With Standard Therapy Chest, January 1, 2007; 131(1): 9 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Lacasse Review: cardioselective {beta} blockers do not produce adverse respiratory effects in COPD Evid. Based Med., June 1, 2006; 11(3): 84 - 84. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
