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Lymphocytic interstitial pneumonia associated with common variable immunodeficiency resolved with intravenous immunoglobulins

¹ Department of Medicine C, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
² Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
³ Institute of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⁴ Institute of Pulmonology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⁵ Department of Cardiothoracic Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Correspondence to:
Correspondence to:
Dr A Rokach
Institute of Pulmonology, Hadassah-Hebrew University Medical Center, P O Box 12000, Jerusalem, Israel 91120; arielr{at}hadassah.org.il

Lymphocytic interstitial pneumonia (LIP) is a rare form of interstitial lung disease. A few case reports have described an association with common variable immunodeficiency (CVID). Corticosteroids are usually used to treat symptomatic patients but their efficacy has never been studied in a controlled trial. We describe a patient with LIP and CVID who was treated monthly with intravenous immunoglobulins (IVIG) without steroids. The patient improved dramatically. We believe that, in selected cases of LIP and immunodeficiency, IVIG given monthly should be considered as the only treatment without adding steroids.

Abbreviations: BOOP, bronchiolitis obliterans organising pneumonia; CVID, common variable immunodeficiency; IVIG, intravenous immunoglobulins; LIP, lymphocytic interstitial pneumonia

Keywords: interstitial lung disease; lymphocytic interstitial pneumonia; common variable immunodeficiency; immunoglobulins; corticosteroids

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				M A Valdivia-Arenas and N Sood Lymphocytic interstitial pneumonia and pulmonary embolism in a patient with tetralogy of Fallot and common variable immunodeficiency: is there any link? Thorax, May 1, 2008; 63(5): 470 - 471. [Abstract] [Full Text] [PDF]