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COUGH |
1 Centre for Digestive Diseases, Leeds General Infirmary, Leeds, UK
2 Centre for Epidemiology and Biostatistics, Medical School, Leeds University, Leeds, UK
3 Gastroenterology Division, McMaster University, Health Sciences Center, Hamilton, Ontario, Canada
4 Division of Academic Medicine, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire HU16 5JQ, UK
Correspondence to:
Correspondence to:
Professor A H Morice
Division of Academic Medicine, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire HU16 5JQ, UK; a.h.morice{at}hull.ac.uk
Background: The prevalence and severity of chronic cough in the community is uncertain. In a large population of representative normal subjects, we explored the relationship between self-reported cough severity and frequency, and factors known to be related to the aetiology of chronic cough. In particular, we have examined the relative association between cough and symptoms of gastrointestinal disease.
Methods: A cross-sectional survey was undertaken in 36 general practices with subjects randomly selected from practice computer databases. Baseline lifestyle and demographic characteristics were recorded. Participants were asked how often in the previous 2 months they had experienced bouts or spasms of coughing. Cough symptom status was dichotomised into symptomatic using a cut off of bouts or spasms of coughing at a frequency of between once a week and once a day or above. Gastrointestinal data were collected using validated methodology.
Results: Questionnaires were sent to 6416 subjects and 4003 (62%) responded. The prevalence of chronic cough was 12%, and was severe in 7%. Following multivariate analysis, regurgitation (OR 1.71; 99% CI 1.20 to 2.45) and irritable bowel syndrome (OR 2.00; 99% CI 1.47 to 2.72) were strong predictors of cough. Smoking (OR 1.61; 99% CI 1.18 to 2.19), declining social class (OR 1.63; 99% CI 1.04 to 2.57), and quality of life at baseline (OR 1.63; 99% CI 1.13 to 2.35) were also significantly associated.
Conclusion: Chronic cough is a common symptom in the general population. Its strong association with gastrointestinal disease may have aetiological significance.
Abbreviations: BMI, body mass index; IBS, irritable bowel syndrome; NSAID, non-steroidal anti-inflammatory drug
Keywords: cough; gastro-oesophageal reflux; prevalence; survey; irritable bowel syndrome
This article has been cited by other articles:
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  A. Morice Review Series: Chronic cough: Epidemiology Chronic Respiratory Disease, February 1, 2008; 5(1): 43 - 47. [Abstract] [PDF]
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 N M Haley and A H Morice Bronchial hyperresponsiveness (BHR) and physical activity Thorax, January 1, 2008; 63(1): 89 - 90. [Full Text] [PDF]
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L.P.A. McGarvey, L. Polley, and J. MacMahon Review Series: Chronic cough: Common causes and current guidelines Chronic Respiratory Disease, November 1, 2007; 4(4): 215 - 223. [Abstract] [PDF]
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A. H Morice Gastro-oesophageal reflux and tachykinins in asthma and chronic cough Thorax, June 1, 2007; 62(6): 468 - 469. [Full Text] [PDF]
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 A. H. Morice, M. S. Menon, S. A. Mulrennan, C. F. Everett, C. Wright, J. Jackson, and R. Thompson Opiate Therapy in Chronic Cough Am. J. Respir. Crit. Care Med., February 15, 2007; 175(4): 312 - 315. [Abstract] [Full Text] [PDF]
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