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Tubular aggregate myopathy presenting with acute type II respiratory failure and severe orthopnoea

¹ Department of Neurology, Queen’s Medical Centre, Nottingham, UK
² Department of Respiratory Medicine, Nottingham City Hospital, Nottingham, UK
³ Department of Histopathology, Queen’s Medical Centre, Nottingham, UK
⁴ Department of Respiratory Medicine, Queen’s Medical Centre, Nottingham, UK

Correspondence to:
Correspondence to:
Dr N Shahrizaila
Department of Neurology, Queen’s Medical Centre, Nottingham NG7 1UH, UK; tshahrizaila{at}hotmail.com

Acute hypercapnic respiratory failure (AHRF) is a common reason for hospital admission. Most patients have an underlying chronic lung disease such as chronic obstructive pulmonary disease. We report the case of a man who presented with AHRF secondary to tubular aggregate myopathy.

Abbreviations: AHRF, acute hypercapnic respiratory failure; COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; NIV, non-invasive ventilation

Keywords: tubular aggregates; myopathy; diaphragm paralysis; hypercapnic respiratory failure