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CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
1 CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
2 Department of Medicine, University of Western Australia, Perth, Australia
3 Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
4 Division of Geriatric Medicine, University of Pittsburgh, PA, USA
5 Preventive Sciences Group, University of California, San Francisco, CA, USA
6 School of Human Movement Studies, University of Queensland, Australia
7 Pulmonary Division, LDS Hospital and University of Utah, Salt Lake City, Utah, USA
8 Clinical Research Branch, National Institute of Aging, Baltimore, MD, USA
9 Geriatric Epidemiology Section, National Institute of Aging, Bethesda, MD, USA
10 Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
Correspondence to:
Correspondence to:
Dr S Yende
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15238, USA; yendes{at}upmc.edu
Background: Inflammatory markers are increased in chronic obstructive pulmonary disease (COPD) and are hypothesised to play an important part in muscle dysfunction and exercise intolerance.
Methods: The Health Aging and Body Composition (Health ABC) study is a prospective observational cohort of well functioning individuals aged 70–79 years. A cross sectional analysis of the baseline data was conducted to examine the association between inflammatory markers and ventilatory limitation, muscle strength, and exercise capacity. These associations were compared in participants with and without obstructive lung disease (OLD).
Results: Of the 3075 participants enrolled in the Health ABC cohort, OLD was identified by spirometric testing in 268 participants and 2005 participants had normal spirometric results. Of the participants with OLD, 35%, 38%, and 27% participants had mild, moderate, and severe OLD, respectively. Participants with OLD had lower quadriceps strength (102.5 Nm v 108.9 Nm, p = 0.02), lower maximum inspiratory pressure (64.7 cm H2O v 74.2 cm H2O, p<0.0001), higher systemic interleukin (IL)-6 levels (2.6 pg/ml v 2.2 pg/ml, p<0.0001), and higher C-reactive protein (CRP) levels (3.5 mg/l v 2.5 mg/l, p<0.0001) than those with normal spirometry. In participants with OLD and those with normal spirometry, forced expiratory volume in 1 second (FEV1) was associated with IL-6 (adjusted regression coefficients (ß) = –5.3 (95% CI –9.1 to–1.5) and –3.1 (95% CI –4.3 to –1.9), respectively). IL-6 and TNF were also associated with quadriceps strength among participants with OLD and those with normal spirometry (ß = –6.4 (95% CI –12.8 to –0.03) and –3.4 (95% CI –5.4 to –1.3), respectively, for IL-6 and ß = –10.1 (95% CI –18.7 to –1.5) and –3.8 (95% CI –7 to –0.6), respectively, for TNF). IL-6, quadriceps strength, and maximum inspiratory pressures were independent predictors of reduced exercise capacity in both groups.
Conclusions: In well functioning elderly subjects with or without OLD, IL-6 is associated with reduced FEV1, quadriceps strength, and exercise capacity.
Abbreviations: CRP, C-reactive protein; FEV1, forced expiratory volume in 1 second; IL, interleukin; OLD, obstructive lung disease; PImax, maximum inspiratory pressure; TNF, tumour necrosis factor
Keywords: C-reactive protein; chronic obstructive lung disease; muscle dysfunction; systemic inflammation; interleukin 6; tumour necrosis factor; exercise capacity
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Thorax 2006 61: 1.
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