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Occasional review
Assessment of progression of COPD: report of a workshop held in Leuven, 11–12 March 2004
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  1. M Decramer1,
  2. R Gosselink1,
  3. M Rutten-Van Mölken2,
  4. J Buffels3,
  5. O Van Schayck4,
  6. P-A Gevenois5,
  7. R Pellegrino6,
  8. E Derom7,
  9. W De Backer8
  1. 1Respiratory Division, University Hospital, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
  2. 2Institute for Medical Technology Assessment, Erasmus Medical Centre Rotterdam, The Netherlands
  3. 3Department of General Practice, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
  4. 4Department of General Practice, University of Maastricht, Maastricht, The Netherlands
  5. 5Department of Radiology, Erasme University Hospital, Brussels, Belgium
  6. 6Centro di Fisiopatologia Respiratoria e dello Studio della Dispnea, Azienda Ospedaliera S Croce e Carle, 12100 Cuneo, Italy
  7. 7Department of Respiratory Diseases, University of Ghent, Belgium
  8. 8Department of Pulmonary Disease, University of Antwerp, Belgium
  1. Correspondence to:
    Professor M Decramer
    Respiratory Division, University Hospital, Herestraat 49, 3000 Leuven, Belgium; Marc.Decrameruz.kuleuven.ac.be

Abstract

Recently performed long term trials have enhanced the insight into the assessment of progression of COPD. The present review focuses on the initial assessment of COPD in general practice and the assessment of disease progression. Several variables may be used to assess this progression, all of which are associated with significant methodological problems. Finding the appropriate mix of outcome measures to capture all aspects of disease progression is a significant challenge.

  • COPD, chronic obstructive pulmonary disease
  • FEV1, forced expiratory volume in 1 second
  • FVC, forced vital capacity
  • MCID, minimal clinically important difference
  • 6MWD, 6 minute walking distance
  • QoL, quality of life
  • ΔVo2max, change in maximal oxygen consumption
  • ΔWmax, change in maximal work load
  • chronic obstructive pulmonary disease
  • progression
  • spirometry
  • general practice
  • health care resources

https://doi.org/10.1136/thx.2004.028712

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    Footnotes

    • ↵* Costs were converted to 2002 $US using harmonised indices of consumer prices published by EUROSTAT to correct for inflation and purchasing power parities as published by OECD to convert national currencies into $US.

    • This workshop was supported by GlaxoSmithKline-Belgium.