| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
ACUTE LUNG INJURY |
1 Lung Research Group, Division of Medicine, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK
2 Department of Pathology and Microbiology, Homeopathic Hospital Site, University of Bristol, Bristol BS6 6JU, UK
Correspondence to:
Correspondence to:
Dr A B Millar
Lung Research Group, Department of Clinical Science at North Bristol, University of Bristol, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK; Ann.Millar{at}bristol.ac.uk
Background: Non-cardiogenic pulmonary oedema is a characteristic feature of the acute respiratory distress syndrome (ARDS). The properties of vascular endothelial growth factor (VEGF) as a potent vascular permogen and mitogen have led to investigation of its potential role in this condition. Lower VEGF plasma levels have been linked to the presence of the T allele in the +936 CT polymorphism. We hypothesised that the presence of the T allele would be associated with the development and severity of ARDS.
Methods: A cohort of 137 normal subjects, 117 ventilated patients with ARDS, and 103 "at risk" of ARDS were genotyped for the VEGF+936 CT polymorphism. The severity of physiological disturbance and mortality was determined in the ventilated cohorts.
Results: The CT and TT genotype frequencies were increased in ARDS patients compared with both normal subjects (OR 2.01, 95% CI 1.13 to 3.58, p = 0.02) and those "at risk" (OR 2.05, 95% CI 1.02 to 2.20, p = 0.03). In patients with ARDS but not those "at risk", CT and TT genotypes were associated with a higher mean APACHE III score (80.9 (4.3) v 69.3 (2.9), p<0.05).
Conclusion: These data support a role for VEGF in the pathogenesis of ARDS and its associated physiological derangement.
Keywords: acute lung injury; vascular endothelial growth factor; polymorphism
Related Article
Thorax 2005 60: 175a.
This article has been cited by other articles:
|
|
 |
|
  G. Lurje, W. Zhang, A. M. Schultheis, D. Yang, S. Groshen, A. E. Hendifar, H. Husain, M. A. Gordon, F. Nagashima, H. M. Chang, et al. Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer Ann. Onc., June 11, 2008; (2008) mdn368v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Lagan, D. D. Melley, T. W. Evans, and G. J. Quinlan Pathogenesis of the systemic inflammatory syndrome and acute lung injury: role of iron mobilization and decompartmentalization Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L161 - L174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. V. Giannoudis, M. van Griensven, E. Tsiridis, and H. C. Pape The genetic predisposition to adverse outcome after trauma J Bone Joint Surg Br, October 1, 2007; 89-B(10): 1273 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Zhai, M N Gong, W Zhou, T B Thompson, P Kraft, L Su, and D C Christiani Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS Thorax, August 1, 2007; 62(8): 718 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A R L Medford and A B Millar Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm? Thorax, July 1, 2006; 61(7): 621 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. F. Voelkel, R. W. Vandivier, and R. M. Tuder Vascular endothelial growth factor in the lung Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L209 - L221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Carpenter, S. Schomberg, and K. R. Stenmark Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1075 - L1082. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
