| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
ASTHMA |
1 Asthma and Allergy Research Institute Inc and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, Australia
2 Cooperative Research Centre for Asthma, University of Western Australia, Perth, Autralia
3 Western Australian Institute for Medical Research and Centre for Medical Research, University of Western Australia, Perth, Australia
4 Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
5 Telethon Institute for Child Health Research, Perth, Australia
Correspondence to:
Correspondence to:
Associate Professor P J Thompson
Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; aari{at}aari.uwa.edu.au
Background: CD14 functions as a multifunctional receptor for bacterial cell wall components including endotoxin and lipopolysaccharide and is likely to play a role in the polarisation of T lymphocytes into Th1 and Th2 subsets, thereby influencing the cytokine profile and subsequent IgE production in response to antigen/allergen contact in allergic phenotypes. A functional C-159T polymorphism has been described in the promoter region of the gene and has been associated with increased gene expression, atopy, and non-atopic asthma in different ethnic populations. A study was undertaken to examine the association between the C-159T polymorphism and asthma, asthma severity, and atopy in a large Australian white population.
Methods: PCR-RFLP analysis was used to characterise the C-159T polymorphism in mild (n = 264), moderate (n = 225) and severe (n = 79) asthmatic patients and non-asthmatic controls (n = 443), including atopic (n = 688) and non-atopic (n = 323) individuals. Association analyses were performed using 
2 tests.
Results: There was no association between the polymorphism and asthma (p = 0.468) or asthma severity (p = 0.727), and only a very weak association with atopy (p = 0.084). A meta-analysis of all studies conducted to date revealed similar genotypic frequencies in white ethnic populations and confirmed that there was no overall association with atopy (p = 0.52) or asthma (p = 0.23), although there was significant between study heterogeneity (p = 0.01).
Conclusions: This study confirms that there is no association between the CD14 C-159T polymorphism and asthma or asthma severity and a weak association between this polymorphism and atopy in an adult population.
Keywords: CD14; genetics; asthma; atopy
This article has been cited by other articles:
|
|
 |
|
  F. D. Martinez CD14, Endotoxin, and Asthma Risk: Actions and Interactions Proceedings of the ATS, July 1, 2007; 4(3): 221 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kallinich, K. C. Beier, U. Wahn, P. Stock, and E. Hamelmann T-cell co-stimulatory molecules: their role in allergic immune reactions Eur. Respir. J., June 1, 2007; 29(6): 1246 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kabesch A Glitch in the Switch?: Of Endotoxin, CD14, and Allergy. Am. J. Respir. Crit. Care Med., August 15, 2006; 174(4): 365 - 366. [Full Text] [PDF]
|
|
|
|
|
|
A. Bush Update in pediatrics 2005. Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 585 - 592. [Full Text] [PDF]
|
|
|
|
|
|
J. Shi, N. L. A. Misso, D. L. Duffy, B. Bradley, R. Beard, P. J. Thompson, and M-A. Kedda Cyclooxygenase-1 gene polymorphisms in patients with different asthma phenotypes and atopy Eur. Respir. J., August 1, 2005; 26(2): 249 - 256. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
