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Thorax 2004;59:708-712
© 2004 BMJ Publishing Group Ltd & British Thoracic Society


REVIEW SERIES

{alpha}1-Antitrypsin deficiency · 5: Intravenous augmentation therapy: current understanding

J K Stoller1, L S Aboussouan2

1 Division of Medicine, Section of Respiratory Therapy, Cleveland Clinic Lerner School of Medicine, Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
2 Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland OH 44195, USA

Correspondence to:
Correspondence to:
Dr J K Stoller
Division of Medicine, Section of Respiratory Therapy, Cleveland Clinic Lerner School of Medicine, Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA; stollej{at}ccf.org

The biochemical and clinical efficacy of intravenous augmentation therapy in {alpha}1-antitrypsin deficiency is reviewed, adverse events experienced with this treatment are considered, and its cost effectiveness is discussed.


Keywords: {alpha}1-antitrypsin deficiency; augmentation therapy




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