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Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial

¹ Division of Respiratory Medicine, University of Nottingham, Clinical Science Building, Nottingham City Hospital, Nottingham NG5 1PB, UK
² Division of Epidemiology and Public Health, University of Nottingham, Clinical Science Building, Nottingham City Hospital, Nottingham NG5 1PB, UK

Correspondence to:
Correspondence to:
Dr A Fogarty
Division of Respiratory Medicine, University of Nottingham, Clinical Science Building, Nottingham City Hospital, Nottingham NG5 1PB, UK; andrew.fogarty{at}nottingham.ac.uk

Background: Increased dietary vitamin E intake is associated with a reduced incidence of asthma, and combinations of antioxidant supplements including vitamin E are effective in reducing ozone induced bronchoconstriction. A study was undertaken to investigate the effect of supplementation with vitamin E for 6 weeks on bronchial hyperresponsiveness in atopic adults with asthma.

Methods: 72 participants from a clinical trial register of adults with asthma were randomised to receive 500 mg natural vitamin E or matched placebo for 6 weeks in a placebo controlled, double blind parallel group clinical trial. Inclusion criteria included age 18–60 years, maintenance treatment of at least one dose of inhaled corticosteroid per day, a positive skin prick test to one of three common allergens, and bronchial hyperresponsiveness to methacholine (defined as a dose provoking a 20% fall in forced expiratory volume in 1 second (FEV₁) (PD₂₀) of 12.25 µmol). Secondary outcomes were FEV₁, forced vital capacity, mean morning and evening peak flow, symptom scores, bronchodilator use, and serum immunoglobulin E levels.

Results: In the primary intention to treat analysis the change in PD₂₀ was similar in the vitamin E and placebo groups with a mean difference of +0.25 doubling doses of methacholine (95% confidence interval –0.67 to +1.16 greater with vitamin E). There was no effect of vitamin E supplementation on any other measure of asthma control, either in the intention to treat or per protocol analysis. There was also no effect of vitamin E supplementation on serum immunoglobulin levels.

Conclusion: Dietary supplementation with vitamin E adds no benefit to current standard treatment in adults with mild to moderate asthma.

Keywords: vitamin E; asthma

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