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LUNG CANCER |
1 Department of Biochemistry and Biophysics, "F Cedrangolo", Section of Anatomic Pathology, Second University of Naples, Naples, Italy
2 Section of Oncology, "Campus Bio-Medico" University, Rome, Italy
3 Department of Experimental Medicine and Pathology, "La Sapienza" University, Rome, Italy
4 Department of Thoracic Surgery, Second University of Naples, Naples, Italy
5 Department of Cardiological, Respiratory and Thoracic Medical Sciences, Second University of Naples, and Third Division of Infective Diseases, D Cotugno Hospital, Naples, Italy
6 Department of Cardio-Thoracic Surgery, University of Vienna, Austria
7 International Society for the Study of Comparative Oncology (ISSCO), Silver Spring, MD, USA
Correspondence to:
Correspondence to:
Dr A Baldi
Via G Orsi 25, 80128 Naples, Italy; alfonsobaldi{at}tiscali.it
Background: A study was undertaken to analyse the potential prognostic value of the immunohistochemical expression of cyclooxygenase-2 (COX-2) and p27 in 29 malignant mesotheliomas already screened for the expression of p21 and p53.
Methods: Immunohistochemistry was used to determine the expression of COX-2 and p27. The correlation with survival of these factors and of p21 and p53 expression was assessed by univariate and multivariate analyses.
Results: A positive statistically significant correlation was found between p27 and p21 expression (p<0.0001), but there was a negative correlation between COX-2 expression and both p27 (p = 0.001) and p21 (p<0.0001). No statistically significant correlation was recorded between p53 and all the other immunohistochemical parameters. Univariate analysis showed that overall survival was strongly influenced by p21, p27, and COX-2 expression, but multivariate Cox regression analysis showed that the only immunohistochemical parameter to influence overall survival of patients with mesothelioma was COX-2.
Conclusions: These findings suggest that COX-2 expression may be a useful prognostic parameter for mesothelioma.
Keywords: mesothelioma; cyclooxygenase-2; cell cycle inhibitors; prognosis; survival
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