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Sleep · 2: Pathophysiology of obstructive sleep apnoea/hypopnoea syndrome

Division of Sleep Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Correspondence to:
Correspondence to:
Dr R B Fogel
Division of Sleep Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; rfogel{at}partners.org

ABSTRACT
The pathogenesis of airway obstruction in patients with obstructive sleep apnoea/hypopnoea syndrome is reviewed. The primary defect is probably an anatomically small or collapsible pharyngeal airway, in combination with a sleep induced fall in upper airway muscle activity.

Keywords: obstructive sleep apnoea

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