| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
Department of Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, Royal Brompton Hospital, London SW3 6LY, UK
Correspondence to:
Correspondence to:
Professor P J Barnes, Department of Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK;
p.j.barnes{at}ic.ac.uk
Background: Exacerbations are an important feature of chronic obstructive pulmonary disease (COPD), accounting for a large proportion of health care costs. They are associated with increased airway inflammation and oxidative stress.
Methods: Concentrations of leukotriene B4 (LTB4), a marker of inflammation, and 8-isoprostane, a marker of oxidative stress, were measured in the exhaled breath condensate of 21 patients (11 M) with COPD during an exacerbation and 2 weeks after treatment with antibiotics. In 12 patients who had no further exacerbations these markers were also measured after 2 months.
Results: LTB4 concentrations were raised during the COPD exacerbation (mean (SE) 15.8 (1.1) pg/ml and fell after treatment with antibiotics to 9.9 (0.9) pg/ml (p<0.0001). In 12 patients the level of LTB4 fell further from 10.6 (1.1) pg/ml to 8.5 (0.8) pg/ml (p<0.005) after 2 months. In 12 normal age matched subjects the LTB4 levels were 7.7 (0.5) pg/ml. Concentrations of 8-isoprostane were also increased during the exacerbation (13.0 (0.9) pg/ml) and fell after antibiotic treatment to 9.0 (0.6) pg/ml (p<0.0001). In 12 patients there was a further fall from 9.3 (0.7) pg/ml to 6.0 (0.7) pg/ml (p<0.001) after 2 months compared with normal subjects (6.2 (0.4) pg/ml).
Conclusions: Non-invasive markers of inflammation and oxidative stress are increased during an infective exacerbation of COPD and only slowly recover after treatment with antibiotics.
Keywords: chronic obstructive pulmonary disease; exacerbation; inflammation; oxidative stress
Relevant Article
Thorax 2003 58: 283.
This article has been cited by other articles:
|
|
 |
|
  P. J. Barnes Future Treatments for Chronic Obstructive Pulmonary Disease and Its Comorbidities Proceedings of the ATS, December 1, 2008; 5(8): 857 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Do, K. H. Bartlett, H. Dimich-Ward, W. Chu, and S. M. Kennedy Biomarkers of Airway Acidity and Oxidative Stress in Exhaled Breath Condensate from Grain Workers Am. J. Respir. Crit. Care Med., November 15, 2008; 178(10): 1048 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. L. Borrill, K. Roy, and D. Singh Exhaled breath condensate biomarkers in COPD Eur. Respir. J., August 1, 2008; 32(2): 472 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E Sapey, D Bayley, A Ahmad, P Newbold, N Snell, and R A Stockley Inter-relationships between inflammatory markers in patients with stable COPD with bronchitis: intra-patient and inter-patient variability Thorax, June 1, 2008; 63(6): 493 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Bayley, H. Abusriwil, A. Ahmad, and R. A. Stockley Validation of assays for inflammatory mediators in exhaled breath condensate Eur. Respir. J., May 1, 2008; 31(5): 943 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al. Outcomes for COPD pharmacological trials: from lung function to biomarkers Eur. Respir. J., February 1, 2008; 31(2): 416 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Seto, C. Hirota, S. Hirota, and L. J. Janssen E-Ring Isoprostanes Stimulate a Cl Conductance in Airway Epithelium via Prostaglandin E2-Selective Prostanoid Receptors Am. J. Respir. Cell Mol. Biol., January 1, 2008; 38(1): 88 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Wedzicha and J. R. Hurst Structural and Functional Co-conspirators in Chronic Obstructive Pulmonary Disease Exacerbations Proceedings of the ATS, December 1, 2007; 4(8): 602 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Paredes, T. Tazzeo, and L. J. Janssen E-Ring Isoprostane Augments Cholinergic Neurotransmission in Bovine Trachealis via FP Prostanoid Receptors Am. J. Respir. Cell Mol. Biol., December 1, 2007; 37(6): 739 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Montuschi Review: Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications Therapeutic Advances in Respiratory Disease, October 1, 2007; 1(1): 5 - 23. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Yoshida and R. M. Tuder Pathobiology of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease Physiol Rev, July 1, 2007; 87(3): 1047 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lehtonen, P. Oksa, L. Lehtimaki, A. Sepponen, R. Nieminen, H. Kankaanranta, S. Saarelainen, R. Jarvenpaa, J. Uitti, and E. Moilanen Increased alveolar nitric oxide concentration and high levels of leukotriene B4 and 8-isoprostane in exhaled breath condensate in patients with asbestosis Thorax, July 1, 2007; 62(7): 602 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Celli and P. J. Barnes Exacerbations of chronic obstructive pulmonary disease Eur. Respir. J., June 1, 2007; 29(6): 1224 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-L. Corhay, L. Hemelaers, M. Henket, J. Sele, and R. Louis Granulocyte Chemotactic Activity in Exhaled Breath Condensate of Healthy Subjects and Patients With COPD Chest, June 1, 2007; 131(6): 1672 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Kinnula, H. Ilumets, M. Myllarniemi, A. Sovijarvi, and P. Rytila 8-Isoprostane as a marker of oxidative stress in nonsymptomatic cigarette smokers and COPD Eur. Respir. J., January 1, 2007; 29(1): 51 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gaber, F. Acevedo, I. Delin, B-M. Sundblad, L. Palmberg, K. Larsson, M. Kumlin, and S-E. Dahlen Saliva is one likely source of leukotriene B4 in exhaled breath condensate Eur. Respir. J., December 1, 2006; 28(6): 1229 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Liu, T. Tazzeo, and L. J. Janssen Isoprostane-induced airway hyperresponsiveness is dependent on internal Ca2+ handling and Rho/ROCK signaling Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1177 - L1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Kharitonov and P. J. Barnes Exhaled biomarkers. Chest, November 1, 2006; 130(5): 1541 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Goldbart, J. Krishna, R. C. Li, L. D. Serpero, and D. Gozal Inflammatory Mediators in Exhaled Breath Condensate of Children With Obstructive Sleep Apnea Syndrome. Chest, July 1, 2006; 130(1): 143 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Barnes, B. Chowdhury, S. A. Kharitonov, H. Magnussen, C. P. Page, D. Postma, and M. Saetta Pulmonary Biomarkers in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., July 1, 2006; 174(1): 6 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Marian, S. Baraldo, A. Visentin, A. Papi, M. Saetta, L. M. Fabbri, and P. Maestrelli Up-Regulated Membrane and Nuclear Leukotriene B4 Receptors in COPD Chest, June 1, 2006; 129(6): 1523 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Papi, F. Luppi, F. Franco, and L. M. Fabbri Pathophysiology of Exacerbations of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, May 1, 2006; 3(3): 245 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Ochs-Balcom, B. J. B. Grant, P. Muti, C. T. Sempos, J. L. Freudenheim, R. W. Browne, M. Trevisan, L. Iacoviello, P. A. Cassano, and H. J. Schunemann Oxidative Stress and Pulmonary Function in the General Population Am. J. Epidemiol., December 15, 2005; 162(12): 1137 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. Adcock and K. Ito Glucocorticoid Pathways in Chronic Obstructive Pulmonary Disease Therapy Proceedings of the ATS, November 1, 2005; 2(4): 313 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mallia and S. L. Johnston Mechanisms and Experimental Models of Chronic Obstructive Pulmonary Disease Exacerbations Proceedings of the ATS, November 1, 2005; 2(4): 361 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Horvath, J. Hunt, P. J. Barnes, and On behalf of the ATS/ERS Task Force on Exhaled Bre Exhaled breath condensate: methodological recommendations and unresolved questions Eur. Respir. J., September 1, 2005; 26(3): 523 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Brock, Y.-J. Lee, E. Maydanski, T. L. Marburger, M. Luo, R. Paine III, and M. Peters-Golden Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L224 - L232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Barnes and R. A. Stockley COPD: current therapeutic interventions and future approaches Eur. Respir. J., June 1, 2005; 25(6): 1084 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tsoumakidou, N. Tzanakis, G. Chrysofakis, and N. M. Siafakas Nitrosative Stress, Heme Oxygenase-1 Expression and Airway Inflammation During Severe Exacerbations of COPD Chest, June 1, 2005; 127(6): 1911 - 1918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baydur Not All That Comes Out Is Hot Air Chest, May 1, 2005; 127(5): 1482 - 1485. [Full Text] [PDF]
|
|
|
|
|
|
P. J. Barnes, I. M. Adcock, and K. Ito Histone acetylation and deacetylation: importance in inflammatory lung diseases Eur. Respir. J., March 1, 2005; 25(3): 552 - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C M Harrison and C C Andersen Exhaled breath measures of inflammation: are they useful in neonatal chronic lung disease? Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2005; 90(1): F6 - F10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Barnes Mediators of Chronic Obstructive Pulmonary Disease Pharmacol. Rev., December 1, 2004; 56(4): 515 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Kharitonov and P. J. Barnes Effects of Corticosteroids on Noninvasive Biomarkers of Inflammation in Asthma and Chronic Obstructive Pulmonary Disease Proceedings of the ATS, November 1, 2004; 1(3): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Moloney, S. E. Mumby, R. Gajdocsi, J. H. Cranshaw, S. A. Kharitonov, G. J. Quinlan, and M. J. Griffiths Exhaled Breath Condensate Detects Markers of Pulmonary Inflammation after Cardiothoracic Surgery Am. J. Respir. Crit. Care Med., January 1, 2004; 169(1): 64 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.J. Barnes, S.D. Shapiro, and R.A. Pauwels Chronic obstructive pulmonary disease: molecular and cellularmechanisms Eur. Respir. J., October 1, 2003; 22(4): 672 - 688. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
